Publié le par Julien -

Tannic Acid (TA) is an outstanding ingredient, a polyphenol issued from nature and stabilized for the first time by ALPHASCIENCE.

TA has protective capacity superior to reference antioxidants such as BHA, BHT, alpha tocopherol and trolox[1]. It also inhibits hydroxyl radical formation from Fenton Reaction by complexing Fe3+[2].

TA has vascular properties: it binds to vascular elastin, improves resistance to degradation and reduces in vivo calcification[3]. It protects the endothelium of small blood vessels and the capillaries[4]. TA is efficient to treat bruises: the chelation properties help avoiding iron deposit in the skin following vascular injuries and its antioxidant activity protects cell membranes and cellular integrity.

TA inhibits collagenase-induced degradation of collagen via extensive hydrogen bonding augmented by hydrophobic interactions and prevents the free access of collagenase to active sites on the collagen chains[5].

TA is effective against skin tumors: protection against chemically induced skin tumorigenesis in mice with a reduction of 66 % of induced tumours[6], inhibition by 85% of the ODC marker of skin tumor promotion[7].

TA inhibits advanced glycation end products formation[8] and has antifungal and antibacterial activities[9], which could explain the link between its presence in the bark of Sequoia and exceptional lifespan of Sequoia.

To sum up, TA presents unique topical and cosmetics aplications: bruises and redness, anti-aging, anti-pollution, free radical protection and scavenging, vasoprotection and regulation of pigmentation.

 

[1] Rice-Evans, 1995 and Liyana-Pathirana and Shahidi, 2006

[2] Lopes GK, Biochim biophys Acta 1999, 10.1472-142,152

[3] Yanni Xu, Peng Liu, Suowen Xu, Marina Koroleva, Shuya Zhang, Shuyi Si & Zheng Gen Jin

[4] Biomaterials:
Volume 27, Issue 19, July 2006, Pages 3645-3651 Jason C. Isenburg, Nishant V. Karamchandani, Dan T. Simionescu, Narendra R. Vyavahare

[5] K Jackson J. Mater. Sci. 2010,21,1435-1443

[6] Mukul Das et all, International Journal of Cancer 43, 3, 468-470

[7] Hala U Gall,Cancer Res 1991, 51,2820

[8] Curr.Drug Metab.2013, may, 14 414-431

[9] Hisanori Akiyama, J. antimicrobial Chemotherapy, 48, 4 ; 487-491

Tannic Acid (TA) is an outstanding ingredient, a polyphenol issued from nature and stabilized for the first time by ALPHASCIENCE.

TA has protective capacity superior to reference antioxidants such as BHA, BHT, alpha tocopherol and trolox[1]. It also inhibits hydroxyl radical formation from Fenton Reaction by complexing Fe3+[2].

TA has vascular properties: it binds to vascular elastin, improves resistance to degradation and reduces in vivo calcification[3]. It protects the endothelium of small blood vessels and the capillaries[4]. TA is efficient to treat bruises: the chelation properties help avoiding iron deposit in the skin following vascular injuries and its antioxidant activity protects cell membranes and cellular integrity.

TA inhibits collagenase-induced degradation of collagen via extensive hydrogen bonding augmented by hydrophobic interactions and prevents the free access of collagenase to active sites on the collagen chains[5].

TA is effective against skin tumors: protection against chemically induced skin tumorigenesis in mice with a reduction of 66 % of induced tumours[6], inhibition by 85% of the ODC marker of skin tumor promotion[7].

TA inhibits advanced glycation end products formation[8] and has antifungal and antibacterial activities[9], which could explain the link between its presence in the bark of Sequoia and exceptional lifespan of Sequoia.

To sum up, TA presents unique topical and cosmetics aplications: bruises and redness, anti-aging, anti-pollution, free radical protection and scavenging, vasoprotection and regulation of pigmentation.

 

[1] Rice-Evans, 1995 and Liyana-Pathirana and Shahidi, 2006

[2] Lopes GK, Biochim biophys Acta 1999, 10.1472-142,152

[3] Yanni Xu, Peng Liu, Suowen Xu, Marina Koroleva, Shuya Zhang, Shuyi Si & Zheng Gen Jin

[4] Biomaterials:
Volume 27, Issue 19, July 2006, Pages 3645-3651 Jason C. Isenburg, Nishant V. Karamchandani, Dan T. Simionescu, Narendra R. Vyavahare

[5] K Jackson J. Mater. Sci. 2010,21,1435-1443

[6] Mukul Das et all, International Journal of Cancer 43, 3, 468-470

[7] Hala U Gall,Cancer Res 1991, 51,2820

[8] Curr.Drug Metab.2013, may, 14 414-431

[9] Hisanori Akiyama, J. antimicrobial Chemotherapy, 48, 4 ; 487-491